Reproducibility of BOLD localization of interictal activity in patients with focal epilepsy: intrasession and intersession comparisons
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ilaria Pesaresi · Mirco Cosottini · Gina Belmonte · Patrizia Maritato · Mario Mascalchi · Michele Puglioli · Ferdinando Sartucci · Carlo Bartolozzi
- چاپ و سال / کشور: 2011
Description
Object Simultaneous EEG-fMRI recordings allow the identification of haemodynamic changes induced by neuronal activity during ictal or interictal epileptiform events (IEDs).We evaluated the reproducibility of continuous EEGfMRI (cEEG-fMRI) in patients with focal epilepsy. Materials and methods We studied 15 patients with focal epilepsy (8 cryptogenic and 7 symptomatic) and frequent interictal abnormalities. Each patient underwent two cEEGfMRI acquisitions (runs) in the same day (session) and 8 patients repeated the examination after one month. cEEGfMRI reproducibility was defined by the existence of partially overlapping clusters between activation maps obtained from different runs. Results We detected IEDs in 40 out of 46 EEG-fMRI runs and a related significant BOLD-response in all 40 runs. A prevalent positive BOLD response was detected in 12 patients and a prevalent negative response in 3 subjects. Statistical maps included a mean of 10 significant clusters. Nearly30%of clusters were reproducible in both intrasession and intersession comparisons, with a mean overlap of 30%. Reproducibility did not differ between positive and negative BOLD-responses.Discussion Among the reproducible clusters, those with the highest percentage of overlap were concordant with the EEG electric field in all patients and they were localized in the same lobe as the brain lesion in patients with symptomatic epilepsy. We hypothesize that reproducible clusters could be more consistently related to the irritative zone than nonreproducible ones. Conclusion The evaluation of cluster reproducibility could improve our knowledge of IED-related BOLD response. Moreover, it could enhance the reliability of cEEG-fMRI to identify the irritative zone in focal epileptic patients.
Magn Reson Mater Phy DOI 10.1007/s10334-011-0263-x Received: 13 November 2009 / Revised: 31 May 2011 / Accepted: 31 May 2011
