Remodeling of the infarct territory in the time course of infarct healing in humans
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hanns B. Hillenbrand · Joern Sandstede · Stefan Stِrk · Benjamin Ramsayer · Dietbert Hahn · Georg Ertl · Herbert Koestler · Wolfgang Bauer · Christ
- چاپ و سال / کشور: 2011
Description
Object To analyze the remodeling processes of the infarct territory in the time course of infarct healing. Materials and methods Serial late enhancement (LE) studies were performed in 30 patients following reperfused myocardial infarction (MI) in the first and second week post-MI and after 3 months. To characterize infarct remodeling over time, the following variables were derived and analyzed in a blinded fashion: Infarct size (IS, in mm3), maximum infarct thickness (ITmax, mm), mean infarct thickness (ITmean, mm) and the variability of infarct thickness (VIT=ITmax/ITmean). Further, a newparameter for the assessment of infarct remodeling, the infarct extent (IE, mm2) was computed. IE quantifies IS in two dimensions along the heart’s circumferential and longitudinal directions. ISwas divided by the IE to obtain ITmean. Results Overall infarct thicknesswas highly variable. Infarct shrinkage due to infarct thinning and IE reduction was found in the first months of healing. IS, ITmean and ITmax significantly decreased during follow-up. There was a less consistent change of the IE: IE decreased in 75% of all infarcts from the first week up to 3months post-MI, whereas 25% of infarcts expanded. Infarct thinning was found in almost all patients (92%), hence occurring in patients with infarct expansion and in patients without infarct expansion. Conclusion Infarct thinning and—to a lesser extent—IE reduction, contribute to infarct shrinkage in the time course of infarct healing. Infarct thinning may occur without infarct expansion.
Magn Reson Mater Phy DOI 10.1007/s10334-011-0262-y Received: 4 September 2009 / Revised: 23 May 2011 / Accepted: 25 May 2011
