Temperature dependence of the magnetic volume susceptibility of human breast fat tissue: an NMR study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Sara M. Sprinkhuizen · Chris J. G. Bakker · Johannes H. Ippel · Rolf Boelens · Max A. Viergever · Lambertus W. Bartels
- چاپ و سال / کشور: 2011
Description
Object Proton resonance frequency shift (PRFS)-based MR thermometry (MRT) is hampered by heat-induced susceptibility changes when applied in tissues containing fat, e.g., the human breast. In order to assess the impact of fat susceptibility changes on PRFS-based MRT during thermal therapy in the human breast, reliable knowledge of the temperature dependence of the magnetic volume susceptibility of fat, dƒشfat/dT , is a prerequisite. In thisworkwe havemeasured dƒشfat/dT of human breast fat tissue, using a double-reference method to ensure invariance to temperature-induced changes in the proton electron screening constant. Materials and methods Ex vivo measurements were taken on a 14.1 T five mm narrow bore NMR spectrometer. Breast fat tissue samples were collected from six subjects, directly postmortem. The susceptibility wasmeasured over a temperature range from 24.C to 65.C. Results A linear behavior of the susceptibility over temperaturewas observed for all samples. The resulting dƒشfat/dT of human breast fat ranged between 0.0039 and 0.0076 ppm/ .C. Conclusion It is concluded that the impact of heat-induced susceptibility changes of fat during thermal therapy in the breast may not be neglected.
Magn Reson Mater Phy DOI 10.1007/s10334-011-0250-2 Received: 22 November 2010 / Revised: 25 February 2011 / Accepted: 28 March 2011
