A retrospective study of the impact of age on patterns of care for elderly patients with metastatic breast cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kenji Hashimoto • Kan Yonemori • Chikako Shimizu • Akihiro Hirakawa • Harukaze Yamamoto • Makiko Ono • Taizo Hirata • Tsutomu Kouno • Kenji Tamura • N
- چاپ و سال / کشور: 2010
Description
This study aims at evaluating the impact of age on patterns of care in elderly patients with metastatic breast cancer (MBC) and their outcome. We identified 177 patients aged C65 treated for MBC at the National Cancer Center Hospital in Japan from 1999 to 2007. We evaluated the impact of age on the selection of best supportive care (BSC) only, chemotherapy as first-line treatment, and chemotherapy after first-line endocrine therapy. Fisher’s exact test and a multivariate logistic regression analysis with variables of age, performance status (PS), hormone receptor (HR) status, human epidermal growth factor-2 (HER2), and life-threatening disease (LTD) were used. The median age of patients was 72, and 60 patients (33.9%) were aged C75. HR-negative patients and those whose PS was C2, regardless of age, were more likely to choose BSC without chemotherapy. Multivariate analysis revealed age C 75 (P = 0.018), positive-HR status (P\0.001), and absence of LTD (P\0.001) were significantly correlated to choose endocrine therapy rather than chemotherapy. In patients who had previous endocrine therapy, age (P = 0.008) and absence of HER2 (P = 0.018) were related not to choose chemotherapy. Not age but HRnegative status or PS C 2 were related to the selection of BSC. In selecting endocrine therapy rather than chemotherapy, age (C75), HR-positive, and absence of LTD were significant factors. In patients failed to endocrine therapy, age and HER2 status were correlated to decision-making to choose chemotherapy
Med Oncol (2011) 28:434–440 DOI 10.1007/s12032-010-9497-0 Received: 9 March 2010 / Accepted: 11 March 2010 / Published online: 31 March 2010
