Gender Influences Cerebral Oxygenation After Red Blood Cell Transfusion in Patients with Severe Traumatic Brain Injury
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Victoria Arellano-Orden • Santiago R. Leal-Noval • Aurelio Cayuela • Manuel Munکoz-Go´mez • Carmen Ferra´ndiz-Millo´n • Claudio Garc´a-Alfaro • Ant
- چاپ و سال / کشور: 2011
Description
Background Important differences with respect to gender exist in the prognosis and mortality of traumatic brain injury (TBI) patients. The objective of this study was to assess the role of gender as an independent factor in cerebral oxygenation variations following red blood cell transfusion (RBCT). Methods This retrospective analysis of a prospective study was conducted on patients with severe TBI. Hemoglobin levels were measured at baseline and 6 h after transfusion. Brain tissue oxygen pressure (PbrO2), cerebral perfusion pressure (CPP), intracranial pressure (ICP), and mean arterial pressure (MAP) were measured at baseline, at the end of RBCT and at 1, 2, 3, 4, 5, and 6 h after transfusion. After the patients were stratified into two groups according to gender, the effect of RBCT on PbrO2 (cerebral oxygenation) was analyzed using a multivariate analysis of variance with repeated measures (MANOVA). The MANOVA was repeated after adjusting for all covariables with baseline differences between groups. Results At baseline, we found differences in age (P = 0.01), weight (P = 0.03), MAP (P = 0.01), ISS (P = 0.05), and CCP (P = 0.01) between the groups. After adjusting for these co-variables, we observed that gender and age were related to the increase in PbrO2 (P = 0.05 and P = 0.04, respectively). Conclusions Our results suggest that the effect of RBCT on cerebral oxygenation, as measured by PbrO2, is greater in women than in men.
Neurocrit Care (2011) 14:18–23 DOI 10.1007/s12028-010-9441-3 Published online: 14 September 2010
