Anti-Adrenergic Medications and Edema Development after Intracerebral Hemorrhage
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : L. H. Sansing • S. R. Messe • B. L. Cucchiara • P. D. Lyden • S. E. Kasner
- چاپ و سال / کشور: 2011
Description
Background Use of antihypertensive medications is common after intracerebral hemorrhage (ICH). Medications that block adrenergic activation (e.g., beta-blockers and the alpha(2)-agonist, clonidine) may reduce the inflammatory response and therefore have secondary benefit after ICH. Methods The patients with acute ICH enrolled in the placebo arm of the CHANT trial were included. Univariate and multivariate analyses were undertaken for factors associated with blood pressure medication use, edema at 72 h, and clinical outcome at 90 days. Results Of the 303 patients, 87.8% received some antihypertensive treatment during the first 72 h of hospitalization. Edema volume on neuroimaging at 72 h was independently associated with clinical outcome. Use of anti-adrenergic medications was associated with less edema after controlling for hemorrhage volume and blood pressure. Conclusions Antihypertensive medications that antagonize the sympathetic nervous system may reduce perihematomal edema after ICH.
Neurocrit Care (2011) 14:395–400 DOI 10.1007/s12028-010-9498-z Published online: 25 January 2011
