Electroacupuncture enhances cell proliferation and neuronal differentiation in young rat brains
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jianfeng Gao • Sheng Wang • Xiaoyang Wang • Changlian Zhu
- چاپ و سال / کشور: 2011
Description
To investigate the effect of electroacupuncture on cell proliferation and differentiation in young rat hippocampus, postnatal day-14 rats were assigned randomly to control, ketamine anesthesia, nonacupoint, or acupoint electroacupuncture groups. Electroacupuncture was applied at bilateral acupoints (Quchi, Waiguan, Huantiao, and Zusanli) 30 min daily for 7 successive days. The proliferation and neuronal differentiation of proliferated surviving cells in the dentate gyrus were evaluated at 4 weeks after last stimulation. The stimulatory effect of electroacupuncture on cell proliferation had a long-lasting effect, as indicated by the increased phosphor-histone H3-positive cells. The number of proliferated and survival cells, indicated by BrdU labeling, was highest in the electroacupuncture group. The number of newly differentiated neurons, as indicated by BrdU/NeuN double labeling, was significantly higher in the electroacupuncture group than in any of the other groups. This finding provides a theoretical basis for the clinical application of acupuncture to cerebral injury rehabilitation in children
Neurol Sci (2011) 32:369–374 DOI 10.1007/s10072-010-0402-6 Received: 31 January 2010 / Accepted: 28 August 2010 / Published online: 18 September 2010
