The usefulness of albumin-adjusted ischemia-modified albumin index as early detecting marker for ischemic stroke
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jung Hwan Ahn • Sang Cheon Choi • Wee Gyo Lee • Yoon Seok Jung
- چاپ و سال / کشور: 2010
Description
This study was conducted to investigate whether albumin-adjusted ischemia-modified albumin index (IMA index) is more sensitive and accurate than ischemiamodified albumin (IMA) as early detection marker of ischemic stroke, and to compare IMA and IMA index in progression and non-progression of ischemic stroke. This case–control study was done at an emergency medical center of a university hospital. 52 patients with neurological symptoms were enrolled (28 Ischemic Stroke Group and 24 Non-Stroke Group). In the ROC analysis of IMA index to diagnose stroke, area under the curve (AUC) was 0.990 (cutoff value 91.4; 95% CI: 0.970–1.000; sensitivity: 95.8%; specificity: 96.4%). The AUC for IMA value was 0.928 (cutoff value 98 U/ml; 95% CI: 0.857–0.999; sensitivity: 87.5%; specificity: 89.3%). The difference between progression (n = 12) and non-progression group (n = 16) in IMA and IMA index were statistically insignificant (p[0.01). IMA index was more sensitive than conventional IMA value as diagnostic biomarker of stroke, however, arguable as a predictive biomarker for progression of ischemic stroke.
Neurol Sci (2011) 32:133–138 DOI 10.1007/s10072-010-0457-4 Received: 31 January 2008 / Accepted: 17 November 2010 / Published online: 11 December 2010
