Serotonin toxicity: a short review of the literature and two case reports involving Citalopram
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : G. Talarico • G. Tosto • S. Pietracupa • E. Piacentini • M. Canevelli • G. L. Lenzi • G. Bruno
- چاپ و سال / کشور: 2011
Description
The serotonin toxicity (ST) is a potentially lifethreatening adverse drug reaction results from therapeutic drug use, intentional self-poisoning, or inadvertent interactions between drugs. ST can be caused by a single or a combination of drugs with serotonergic activity due to excessive serotonergic agonism on central nervous system and peripheral serotonergic receptors (monoamine oxidase inhibitors, tricyclic antidepressants, SSRIs, opiate analgesics, over-the-counter cough medicines, antibiotics, weightreduction agents, antiemetics, antimigraine agents, drugs of abuse, H2-antagonist and herbal products). The serotonin toxicity is often described as a clinical triad of mental-status changes (agitation and excitement with confusion), autonomic hyperactivity (diaphoresis, fever, tachycardia, and tachypnea), neuromuscular abnormalities (tremor, clonus, myoclonus, and hyperreflexia) and, in the advanced stage, spasticity; not all of these findings are consistently present. In this article, we describe two cases of ST due to interaction between Citalopram and two CYP2D6 inhibitors: Cimetidine and Topiramate and their clinical resolution after treatment discontinuation.
Neurol Sci (2011) 32:507–509 DOI 10.1007/s10072-011-0546-z Received: 25 February 2010 / Accepted: 16 March 2011 / Published online: 14 April 2011
