Microscopic polyangiitis presenting with peripheral and central neurological manifestations
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : S. Ben Sassi • I. Ben Ghorbel • H. Mizouni • M. H. Houman • F. Hentati
- چاپ و سال / کشور: 2011
Description
Although peripheral neuropathy is a common complication of microscopic angiitis, manifestations involving themuscle and the central nervous systemhave been rarely reported. We describe a 48-year-old man who rapidly developed a clinical picture of mononeuritis multiplex. A month after the appearance of the primary symptoms, he became comatose and had left hemiplegia in relation with a massive cerebral haematoma. Laboratory data revealed signs of inflammation, glomerular dysfunction withmicrohaematuria, and positive myeloperoxidase-antineutrophil cytoplasmic antibodies. The neuromuscular biopsy disclosed a smallvessel vasculitis, consisting with microscopic angiitis, associated with myositis and extensive axonal loss. The patient had surgical evacuation of the haematoma and received immunosuppressive therapy with good outcome. Thus, microscopic angiitis should be considered as a differential diagnosis in cases of myositis and intracerebral haemorrhage.
Neurol Sci (2011) 32:727–729 DOI 10.1007/s10072-011-0653-x Received: 17 September 2009 / Accepted: 2 June 2011 / Published online: 17 June 2011
