Marburg’s disease: a diagnostic dilemma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kirti Gupta • Rakesh Kumar Vasishta • Param Singh Kharbanda • Sameer Vyas • Sudesh Prabhakar
- چاپ و سال / کشور: 2011
Description
This report describes the clinical, radiological and autopsy findings of a young male suffering from acute, monophasic demyelinating disease presenting with acute onset of altered sensorium and a short past history of progressive multiple neurological deficits. The radiological findings revealed acute infarcts in the territory of anterior cerebral artery. The antemortem diagnosis centred on an infective (tubercular) aetiology leading to demyelination based on presence of tubercle bacilli in bronchoalveolar lavage (BAL) fluid. The autopsy revealed multiple subacute and acute plaques showing demyelination, giant astrocytes, numerous macrophages and little perivascular inflammation, thereby confirming the diagnosis of Marburg’s type of multiple sclerosis. Marburg’s type is a fulminant demyelinating disorder characterised by a severe, rapidly evolving clinical course. Death occurs due to brain stem involvement or severe widespread cerebral lesions.
Neurol Sci DOI 10.1007/s10072-011-0728-8 Received: 15 December 2010 / Accepted: 19 July 2011
