The appearance of ADCs in the non-affected areas of the patients with MELAS
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Zhenghua Liu & Xiwei Liu & Lihong Hui & Danhua Zhao & Xiaoying Wang & Sheng Xie & Jiangxi Xiao & Xuexiang Jiang
- چاپ و سال / کشور: 2011
Description
Introduction The exact mechanism of the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) remain unclear. Diffusion-weighted imaging (DWI) is a magnetic resonance (MR) imaging technique for studying the pathophysiologic change of the MELAS. The purpose of the study is to see whether the apparent diffusion coefficient (ADC) of MELAS in the non-affected areas is different from the ADC of the normal subjects and to speculate the pathophysiological mechanisms of the MELAS. Methods Sixteen cases of MELAS were retrospectively analyzed. Thirty healthy subjects were chosen to constitute the control group. All of them were performed on the 3.0T whole-body MR scanner with axial view T2 fluid attenuated inversion recovery (flair), T2-weighted imaging, T1flair, and DWI. An ADC map was reconstructed in the workstation. Two to five regions of interest were put in the non-affected frontal lobe and basal ganglia. All data took statistical analysis. Results There were significant differences between the ADC of the patients with MELAS and the controls in the non-affected areas, including the superior frontal gyrus, precentral gyrus, corpus striatum, thalamus, and white matter of the semi-oval centrum. Conclusion ADCs in the non-affected areas of the patients with MELAS are higher than those of the normal subjects. Pathological changes take place in the non-affected areas of the patients with MELAS.
Neuroradiology (2011) 53:227–232 DOI 10.1007/s00234-010-0729-y Received: 3 April 2010 / Accepted: 4 June 2010 / Published online: 17 June 2010
