Use of diffusion tensor imaging to identify similarities and differences between cerebellar and Parkinsonism forms of multiple system atrophy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Po-Shan Wang & Hsiu-Mei Wu & Ching-Po Lin & Bing-Wen Soong
- چاپ و سال / کشور: 2011
Description
Introduction We performed diffusion tensor imaging to determine if multiple system atrophy (MSA)-cerebellar (C) and MSA-Parkinsonism (P) show similar changes, as shown in pathological studies. Methods Nineteen patients with MSA-C, 12 patients with MSA-P, 20 patients with Parkinson disease, and 20 healthy controls were evaluated with the use of voxel-based morphometry analysis of diffusion tensor imaging. Results There was an increase in apparent diffusion coefficient values in the middle cerebellar peduncles and cerebellum and a decrease in fractional anisotropy in the pyramidal tract, middle cerebellar peduncles, and white matter of the cerebellum in patients with MSA-C and MSA-P compared to the controls (P<0.001). In addition, isotropic diffusion-weighted image values were reduced in the cerebellar cortex and deep cerebellar nuclei in patients with MSA-C and increased in the basal ganglia in patients with MSA-P. Conclusion These results indicate that despite their disparate clinicalmanifestations, patients withMSA-C and MSA-P share similar diffusion tensor imaging features in the infratentorial region. Further, the combination of FA, ADC and iDWI images can be used to distinguish between MSA (either form) and Parkinson disease, which has potential therapeutic implications.
Neuroradiology (2011) 53:471–481 DOI 10.1007/s00234-010-0757-7 Received: 11 March 2010 / Accepted: 3 August 2010 / Published online: 25 August 2010
