Diffusion-weighted imaging in acute demyelinating myelopathy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Chiara Zecca & Carlo Cereda & Stephan Wetzel & Silvia Tschuor & Claudio Staedler & Francesco Santini & Navarajah Nadarajah & Claudio L. Bassetti & Cl
- چاپ و سال / کشور: 2011
Description
Introduction Diffusion-weighted imaging (DWI) has become a reference MRI technique for the evaluation of neurological disorders. Few publications have investigated the application of DWI for inflammatory demyelinating lesions. The purpose of the study was to describe diffusion-weighted imaging characteristics of acute, spinal demyelinating lesions. Methods Six consecutive patients (two males, four females; aged 28–64 years) with acute spinal cord demyelinating lesions were studied in a prospective case series design from June 2009 to October 2010. We performed magnetic resonance imaging studies from 2 to 14 days from symptom onset on the patients with relapsing remitting multiple sclerosis (n=3) or clinically isolated syndrome (n=3). Main outcome measures were diffusion-weighted imaging and apparent diffusion coefficient pattern (ADC) of acute spinal cord demyelinating lesions. Results All spinal lesions showed a restricted diffusion pattern (DWI+/ADC-) with a 24% median ADC signal decrease. A good correlation between clinical presentation and lesion site was observed. Conclusion Acute demyelinating spinal cord lesions show a uniform restricted diffusion pattern. Clinicians and neuroradiologists should be aware that this pattern is not necessarily confirmatory for an ischaemic aetiology
Neuroradiology DOI 10.1007/s00234-011-0907-6 Received: 11 April 2011 / Accepted: 28 June 2011
