Weight Loss after Roux-en-Y Gastric Bypass in Obese Patients Heterozygous for MC4R Mutations
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ivy R. Aslan & Guilherme M. Campos & Melissa A. Calton & Daniel S. Evans & Raphael B. Merriman & Christian Vaisse
- چاپ و سال / کشور: 2010
Description
Background Heterozygous mutations in melanocortin-4 receptor (MC4R) are the most frequent genetic cause of obesity. Bariatric surgery is a successful treatment for severe obesity. The mechanisms of weight loss after bariatric surgery are not well understood. Methods Ninety-two patients who had Roux-en-Y gastric bypass (RYGB) surgery were screened for MC4R mutations. We compared percent excess weight loss (%EWL) in the four MC4R mutation carriers with that of two control groups: 8 matched controls and with the remaining 80 patients who underwent RYGB. Results Four patients were heterozygous for functionally significant MC4R mutations. In patients with MC4R mutations, the %EWL after RYGB (66% EWL) was not significantly different compared to matched controls (70% EWL) and non-matched controls (60% EWL) after 1 year of follow-up. Conclusions This study suggests that patients with heterozygous MC4R mutations also benefit from RYGB and that weight loss may be independent of the presence of such mutations.
OBES SURG (2011) 21:930–934 DOI 10.1007/s11695-010-0295-8 Published online: 19 October 2010
