Predictive values of calcaneal quantitative ultrasound and dual energy X ray absorptiometry for non-vertebral fracture in older men: results from the MrOS study (Hong Kong)
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : T. Kwok & C. C. Khoo & J. Leung & A. Kwok & L. Qin & J. Woo & P. C. Leung
- چاپ و سال / کشور: 2011
Description
Summary Calcaneal QUS is comparable to DXA in predicting non-vertebral fractures in older Chinese men. Introduction The predictive values of calcaneal quantitative ultrasound (QUS) and dual-energy X-ray absorptiometry (DXA) for non-vertebral fractures in older Chinese men were examined. Methods One thousand nine hundred twenty-one Chinese men aged 65–92 years had calcaneal QUS and axial DXA bone mineral density (BMD) measurements. The incidence of non-vertebral fractures was documented. Cox regression and receiver operating curve (ROC) analysis were used to examine the associations of QUS parameters and BMD with the incidence of non-vertebral fractures. Results The duration of follow-up was (mean±SD) 6.5± 1.7 years. One hundred thirty-one non-vertebral fractures were recorded, 71 of which were major fragility fractures. Broadband ultrasound attenuation (BUA) and quantitative ultrasound index (QUI) were significantly associated with non-vertebral fractures and major fragility fractures, with age and fracture history-adjusted hazard ratio (95% CI) of 1.23 (1.03, 1.47) and 1.32 (1.10, 1.59) per standard deviation reduction, respectively, for non-vertebral fractures; 1.32 (1.04, 1.68) and 1.43 (1.11, 1.84), respectively, for major fragility fractures. Age and fracture historyadjusted areas under ROC curves of hip or spine BMDs were significantly greater than that of BUA or QUI in predicting major fragility fractures, but not in predicting all non-vertebral fractures. The addition of BUA or QUI had no effect on AUCs of total hip BMD alone. Conclusions The ability of calcaneal QUS to predict nonvertebral fractures was comparable to that of axial BMD by DXA, but was inferior to BMD in predicting major fragility fractures in older Chinese men.
Osteoporos Int DOI 10.1007/s00198-011-1634-x Received: 27 July 2010 / Accepted: 2 March 2011
