Teriparatide increases the maturation of circulating osteoblast precursors
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : P. D’Amelio & C. Tamone & F. Sassi & L. D’Amico & I. Roato & S. Patanè & M. Ravazzoli & L. Veneziano & R. Ferracini & G. P. Pescarmona & G. C. Isaia
- چاپ و سال / کشور: 2011
Description
Summary This study shows that teriparatide promotes the circulating osteoblast (OB) precursor degree of maturation in patients affected by postmenopausal osteoporosis. Introduction Anabolic treatment with teriparatide has proven effective for the therapy of postmenopausal osteoporosis and significantly reduces the risk of non-vertebral fragility fractures. The aim of this study was to investigate the effect of teriparatide on circulating OB precursors. Methods We evaluated by flow cytometry and real-time PCR the expression of OBs typical markers in peripheral blood mononuclear cells during treatment with teriparatide plus calcium and vitamin D, raloxifene plus calcium and vitamin D or calcium and vitamin D alone at various time points. Serum bone alkaline phosphatase and osteocalcin (OC) were measured as markers of bone turnover. Results Our results show that circulating OB precursors are more numerous and more immature in patients affected by fragility fractures than in osteoporotic patients without fractures. We also show that teriparatide treatment increases the expression of alkaline phosphatase and of OC in OB precursors; thus, it increases their degree of maturation. Conclusions We suggest that teriparatide acts as anabolic agents also by promoting the maturation of OB precursors.
Osteoporos Int DOI 10.1007/s00198-011-1666-2 Received: 1 February 2011 / Accepted: 19 April 2011
