An in vivo comparison of hip structure analysis (HSA) with measurements obtained by QCT
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : K. Ramamurthi & O. Ahmad & K. Engelke & R. H. Taylor & K. Zhu & S. Gustafsson & R. L. Prince & K. E. Wilson
- چاپ و سال / کشور: 2011
Description
Summary In a population of elderly women, bone crosssectional area (CSA), cross-sectional moment of inertia (CSMI), section modulus (Z), femoral neck axis length (FNAL), and width measured with hip structure analysis (HSA) on dual-energy x-ray absorptiometry (DXA) images in the femoral neck and trochanteric regions are highly correlated to quantitative computed tomography (QCT) measurements. Introduction HSA is a method of obtaining measurements of proximal femur structure using 2D DXA technology. This study was designed to examine the correlations between HSA measurements and 3D QCT. Methods Forty-one women (mean age, 82.8±2.5 years) were measured using DXA and a 64-slice CT scanner (1 mm slice thickness, 0.29 mm in plane resolution). HSA parameters were calculated at the narrow neck (NN) and trochanteric (IT) regions on the DXA image. These regions were then translated to anatomically equivalent regions on the QCT dataset by co-registering the DXA image and QCT dataset using four DXA images acquired at different angles. Results At the NN and IT regions, high linear correlations were measured between HSA and QCT for CSA r=0.95 and 0.93, CSMI r=0.94 and 0.93, and Z r=0.93 and 0.89, respectively. All correlations were highly significant (p< 0.001), but there were differences in slope and offset between the two techniques, at least in part due to differences in calibration between the two techniques. FNAL and width of the bone at the NN and IT regions, physical measurements independent of the calibration, were highly correlated (r=0.90–0.95, p<0.001) and had slopes close to 1.0 (range, 0.978 to 1.003). Conclusion CSA, CSMI, Z, FNAL, and width measured by HSA correlate highly to high-resolution QCT.
Osteoporos Int DOI 10.1007/s00198-011-1578-1 Received: 25 August 2010 / Accepted: 31 January 2011
