High fracture probability with FRAX® usually indicates densitometric osteoporosis: implications for clinical practice
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : W. D. Leslie & S. R. Majumdar & L. M. Lix & H. Johansson & A. Oden & E. McCloskey & J. A. Kanis & for the Manitoba Bone Density Program
- چاپ و سال / کشور: 2011
Description
Summary Most patients designated as high risk of fracture using fracture risk assessment tool (FRAXR) with femoral neck bone mineral density (BMD) (i.e., 10-year major osteoporotic fracture probability exceeding 20% or hip fracture exceeding 3%) have one or more T-scores in the osteoporotic range; conversely, almost no high risk patients have normal T-scores at all bone mineral density measurement sites. Introduction We determined the agreement between a FRAXR designation of high risk of fracture [defined as 10-year major osteoporotic fracture probability (.20%) or hip fracture probability (.3%)] and the WHO categorizations of bone mineral density according to T-score. Methods Ten-year FRAXR probabilities calculated with femoral neck BMD were derived using both Canadian and US white tools for a large clinical cohort of 36,730 women and 2,873 men age 50 years and older from Manitoba, Canada. Individuals were classified according to FRAX fracture probability and BMD T-scores alone. Results Most individuals designated by FRAX as high risk of major osteoporotic fracture had a T-score in the osteoporotic range at one or more BMD measurement sites (85% with Canadian tool and 83% with US white tool). The majority of individuals deemed at high risk of hip fracture had one or more T-scores in the osteoporotic range (66% with Canadian tool and 64% with US white tool). Conversely, there were extremely few individuals (<1%) who were at high risk of major osteoporotic or hip fracture with normal T-scores at all BMD measurement sites. Conclusions A FRAX designation of high risk of fracture is usually associated with a densitometric diagnosis of osteoporosis.
Osteoporos Int DOI 10.1007/s00198-011-1592-3 Received: 10 January 2011 / Accepted: 7 February 2011
