Bone structure and turnover in type 2 diabetes mellitus
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : A. Shu & M. T. Yin & E. Stein & S. Cremers & E. Dworakowski & R. Ives & M. R. Rubin
- چاپ و سال / کشور: 2011
Description
Summary We compared skeletal parameters in type 2 diabetic (T2DM) and non-diabetic postmenopausal women. Bone structure by dual energy x-ray absorptiometry (DXA) and HR-pQCT was not different, although procollagen type 1 amino-terminal propeptide (P1NP) and osteocalcin levels were lower in T2DM. Introduction T2DM is associated with increased fracture risk, but, paradoxically, with higher cross-sectional bone density (BMD) as measured by DXA. We sought explanations to this puzzle by investigating detailed structural and biochemical skeletal parameters in T2DM. Methods Cross-sectional comparison of 25 postmenopausal T2DM women and 25 matched controls using DXA, highresolution peripheral quantitative computed tomography (HR-pQCT) and biochemical bone turnover markers. Results BMD by DXA did not differ between T2DM and controls. HR-pQCT assessment also did not differ, with the exception of cortical area at the tibia, which tended to be lower in the diabetics (difference of 12±6 [mean ± SD] mm, p=0.06). P1NP and osteocalcin levels were lower in T2DM as compared to controls (P1NP, 34.3±16 vs. 57.3±28 ng/ml; p=0.005; osteocalcin, 4.5±2 vs. 6.2±2 nmol/L; p=0.001). Conclusions Postmenopausal women with T2DM had lower levels of bone formation markers as compared to controls. Aside from a possible decrease in cortical bone area at a weight-bearing site, bone structure was not altered in T2DM. Lower bone turnover may be a skeletal parameter that is present in T2DM.
Osteoporos Int DOI 10.1007/s00198-011-1595-0 Received: 5 August 2010 / Accepted: 17 February 2011
