Peroxisome Proliferator Activated Receptor-Alpha (PPARa) and PPAR Gamma Coactivator-1alpha (PGC-1a) Regulation of Cardiac Metabolism in Diabetes
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jennifer G. Duncan
- چاپ و سال / کشور: 2011
Description
Cardiovascular disease is a leading cause of mortality among patients with diabetes, and heart failure exists even in the absence of coronary disease. Myocardial metabolism is altered in the diabetic heart as a result of changes in substrate availability secondary to insulin resistance. The nuclear receptor peroxisome proliferator activated receptor-alpha (PPARa) and PPAR-gamma coactivator-1alpha (PGC-1a) play important roles in transcriptional regulation of myocardial metabolism and contribute significantly to the changes that occur in the diabetic heart. This review summarizes the role of PPARa and PGC-1a in myocardial metabolism in the normal heart and in the diabetic heart.
Pediatr Cardiol (2011) 32:323–328 DOI 10.1007/s00246-011-9889-8 Received: 28 December 2010 / Accepted: 10 January 2011 / Published online: 2 February 2011
