Reproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Walter Li • Bolin Niu • Katherine Henderson • Veronika Northrup • Jeffery S. Pollak • Terence Trow • John Fahey • Robert I. White Jr.
- چاپ و سال / کشور: 2011
Description
Patients with pulmonary arteriovenous malformations (PAVMs) are at risk for multiple complications and require close follow-up. We investigated the reproducibility of the 6-minute walk test (6MWT) and exercise stress test (EST) for the evaluation of low oxygen saturation in patients with PAVMs. Twenty-two patients with PAVMs, most of whom had hereditary hemorrhagic telangiectasia (HHT), participated in a Human Investigations Committee-approved protocol. Patients ranged from 9 to 74 years of age (mean 28) and had a broad spectrum of anatomic subtypes of PAVMs, including focal and diffuse. Standard 6MWT and cycle ergometry EST were both performed twice with adequate rest between tests. Heart rate (HR) and oxygen saturation were measured at the beginning and end of each test. Distance walked and maximum resistance was also recorded. The intraclass correlation coefficients (ri) at the end of 6MWT were as follows: HR (ri = 0.940; 95% confidence interval [CI] 0.863–0.975), oxygen saturation (ri = 0.973; 95% CI 0.933–0.989), and distance (ri = 0.942; 95% CI 0.867– 0.975). The ris at the end of EST were as follows: HR (ri = 0.941; 95% CI 0.865–0.975), oxygen saturation (ri = 0.993; 95% CI 0.982–0.997), and maximum resistance (ri = 0.941; 95% CI 0.864–0.975). 6MWT and EST were reproducible measures of exercise capacity and oxygen saturation and are potential adjunct tests in the follow-up assessment for patients with PAVMs.
Pediatr Cardiol (2011) 32:590–594 DOI 10.1007/s00246-011-9917-8 Received: 3 December 2010 / Accepted: 2 February 2011 / Published online: 19 February 2011
