Hemostatic Response in Paediatric Patients Undergoing Cardiopulmonary Bypass Surgery
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Vera Ignjatovic • Jenny Than • Robyn Summerhayes • Fiona Newall • Stephen Horton • Andrew Cochrane • Paul Monagle
- چاپ و سال / کشور: 2011
Description
This prospective, single-center cohort study aimed to evaluate the hemostatic response during and after Cardiopulmonary Bypass (CPB) surgery in a large cohort of children up to 6 years of age. Blood samples were drawn at eight time points: post-induction of anesthesia, preunfractionated heparin (UFH), post-UFH, post-initiation of bypass, pre-protamine, post-protamine, post-chest-closure, and 6 h post-chest-closure. As expected, all measures of the UFH effect increased significantly post-UFH bolus and decreased post-protamine administration. However, thrombin generation remained inhibited compared to baseline values despite the post-UFH reversal by protamine. We also demonstrate that residual UFH effect is not responsible for the ongoing inhibition of thrombin observed post-protamine administration. The significant increase in both free and total tissue factor pathway inhibitor levels during the CPB surgery might contribute to the persistent thrombin generation/endogenous thrombin potential inhibition post-protamine administration. This study makes a significant and novel contribution by investigating the physiological mechanisms behind the degree of thrombin inhibition by UFH and the residual levels of thrombin inhibition that continue despite protamine reversal and provides a new foundation for future interventional studies in the setting of paediatric CPB surgery.
Pediatr Cardiol (2011) 32:621–627 DOI 10.1007/s00246-011-9929-4 Received: 31 October 2010 / Accepted: 7 February 2011 / Published online: 1 March 2011
