TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Shafic El Hindi & Jochen Reiser
- چاپ و سال / کشور: 2011
Description
Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes.
Pediatr Nephrol (2011) 26:1057–1064 DOI 10.1007/s00467-010-1718-4 Received: 24 August 2010 / Revised: 29 October 2010 / Accepted: 5 November 2010 / Published online: 16 December 2010
