Fetal environment, epigenetics, and pediatric renal disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Robert Woroniecki & Anil Bhanudas Gaikwad & Katalin Susztak
- چاپ و سال / کشور: 2011
Description
The notion that some adult diseases may have their origins in utero has recently captured scientists’ attention. Some of these effects persist across generations and may involve epigenetic mechanisms. Epigenetic modifications, DNA methylation together with covalent modifications of histones, alter chromatin density and accessibility of DNA to cellular machinery, modulating the transcriptional potential of the underlying DNA sequence. Here, we will discuss the different epigenetic modifications and their potential role in and contribution to renal disease development.
Pediatr Nephrol (2011) 26:705–711 DOI 10.1007/s00467-010-1714-8 Received: 24 August 2010 / Revised: 26 October 2010 / Accepted: 27 October 2010 / Published online: 21 December 2010
