Urinary levels of TGF â-1 and of cytokines in patients with prenatally detected nephrouropathies
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mariana A. Vasconcelos & Maria Candida F. Bouzada & Katia D. Silveira & Leticia R. Moura & Fabiana F. Santos & Juliana M. Oliveira & Flavia F. Carval
- چاپ و سال / کشور: 2011
Description
This study aimed to identify noninvasive biomarkers of clinically significant nephrouropathies in patients with antenatal renal and/or urinary tract alterations. Spot-urine levels of interleukin-6 (IL-6), transforming growth factor-â1 (TGF-â1) and tumor necrosis factor-ل (TNF-ل) were measured in 100 patients with antenatal detected nephrouropathies. Patients were divided in idiopathic hydronephrosis (n=47), urinary tract malformations (n=35), and dysplastic kidneys (n=18). Urinary concentrations of TGF-â1, IL-6, and TNF-ل were compared between groups according to clinical and image findings. Receiver-operating characteristic (ROC) curves were analyzed for the overall diagnostic accuracy of TGF-â1, IL-6, and TNF-ل levels in discriminating infants with nephrouropathies. No significant differences in urinary TGF- â1, IL-6, and TNF-ل levels were found in the comparison between the groups. TGF-â1 levels tended to be higher in patients with renal hypodysplasia compared to idiopathic hydronephrosis (p=0.07). Twenty-nine patients had reduced DMSA uptake. In these cases, absolute urinary concentration of TGF-â1 and levels standardized for creatinine were significantly higher than in patients with normal DMSA uptake, while IL6 and TNF-ل did not differ between groups. Urinary cytokine measurements were not useful as a screening test for clinically significant nephrouropathies. Conversely, increased concentrations of TGF-â1 pointed out to renal damage as indicated by reduced DMSA uptake.
Pediatr Nephrol (2011) 26:739–747 DOI 10.1007/s00467-011-1802-4 Received: 5 November 2010 / Revised: 29 December 2010 / Accepted: 25 January 2011 / Published online: 18 February 2011
