Transient hyperoxaluria in a patient with inherited distal renal tubular acidosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ivana Pela & Aldesia Provenzano & Sabrina Giglio
- چاپ و سال / کشور: 2011
Description
Sirs, Persistent secondary hyperoxaluria has been reported in few patients affected by distal renal tubular acidosis (dRTA) [1]. Hyperoxaluria is a genetic or acquired metabolic disorder. The patients affected by type 1 hyperoxaluria (PH1), an autosomal recessive severe condition caused by mutation in the AGXT gene, are at risk of recurrent nephrolithiasis, nephrocalcinosis and end-stage renal disease (ESRD) due to tissue accumulation of oxalate. A marked increase in urinary excretion of oxalate is the most important laboratory report and the diagnosis can be confirmed by the measurement of hepatic enzyme activity [2].
Pediatr Nephrol (2011) 26:323–324 DOI 10.1007/s00467-010-1630-Y Received: 2 July 2010 / Revised: 17 July 2010 / Accepted: 21 July 2010 / Published online: 9 August 2010
