Primary antiphospholipid syndrome presenting as renal vein thrombosis and membranous nephropathy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Swasti Chaturvedi & Leonardo Brandao & Denis Geary & Christoph Licht
- چاپ و سال / کشور: 2011
Description
Antiphospholipid syndrome is a multisystem autoimmune disorder characterized by thrombotic events and the presence of circulating antiphospholipid antibodies. Large vessel involvement in the form of thrombosis/stenosis and thrombotic microangiopathy is a commonly described renal finding. However, non-thrombotic glomerulopathies are increasingly being recognized in patients with antiphospholipid syndrome. We report a rare occurrence of both renal vein thrombosis and membranous nephropathy in a previously healthy adolescent male. Investigations revealed persistently positive antiphospholipid antibodies in the absence of an underlying systemic autoimmune disorder or malignancy. Our patient responded favourably to antiproteinuric therapy and anticoagulation with complete resolution of proteinuria and a nearly occlusive thrombus.
Pediatr Nephrol (2011) 26:979–985 DOI 10.1007/s00467-011-1787-z Received: 8 September 2010 / Revised: 12 January 2011 / Accepted: 17 January 2011 / Published online: 23 March 2011
