Vesico-ureteric reflux: using mouse models to understand a common congenital urinary tract defect
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Inga J. Murawski & Christine L. Watt & Indra R. Gupta
- چاپ و سال / کشور: 2011
Description
Vesico-ureteric reflux (VUR) is a common congenital urinary tract defect in which urine flows retrogradely from the bladder to the kidneys because of an abnormally formed uretero-vesical junction. It is associated with recurrent urinary tract infections, renal hypo/dysplasia, reflux nephropathy, hypertension, and end-stage renal disease. In humans, VUR is genetically and phenotypically heterogeneous, encompassing diverse renal and urinary tract phenotypes. To understand the significance of these phenotypes, we and others have used the mouse as a model organism and this has led to the identification of new candidate genes. Through careful phenotypic analysis of these models, a new understanding of the genetics and biology of VUR is now underway.
Pediatr Nephrol (2011) 26:1513–1522 DOI 10.1007/s00467-011-1821-1 Received: 23 November 2010 / Revised: 22 December 2010 / Accepted: 25 January 2011 / Published online: 20 March 2011
