Fetal programming of renal function
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jِrg Dِtsch & Christian Plank & Kerstin Amann
- چاپ و سال / کشور: 2011
Description
Results from large epidemiological studies suggest a clear relation between low birth weight and adverse renal outcome evident as early as during childhood. Such adverse outcomes may include glomerular disease, hypertension, and renal failure and contribute to a phenomenon called fetal programming. Other factors potentially leading to an adverse renal outcome following fetal programming are maternal diabetes mellitus, smoking, salt overload, and use of glucocorticoids during pregnancy. However, clinical data on the latter are scarce. Here, we discuss potential underlying mechanisms of fetal programming, including reduced nephron number via diminished nephrogenesis and other renal (e.g., via the intrarenal renin–angiotensin–aldosterone system) and non-renal (e.g., changes in endothelial function) alterations. It appears likely that the outcomes of fetal programming may be influenced or modified postnatally, for example, by the amount of nutrients given at critical times.
Pediatr Nephrol DOI 10.1007/s00467-011-1781-5 Received: 9 November 2010 / Revised: 9 December 2010 / Accepted: 15 December 2010
