Longitudinal study of bone mineral density in children with idiopathic hypercalciuria
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Maria Goretti Moreira Guimarمes Penido & Marcelo de Sousa Tavares & Mariana Campos Linhares & Ana Carolina Silva Barbosa & Maarmed Cunha
- چاپ و سال / کشور: 2011
Description
Children with idiopathic hypercalciuria (IH) may have a reduced bone mineral density (BMD), which could impact on bone health in adulthood. There is currently no strong evidence for a preferred treatment of such children. The aim of our study was to evaluate the BMD z-score before and after treating children and adolescents with IH with potassium citrate and thiazides. The study consisted of a historical cohort of 80 pediatric patients who were evaluated between October 1989 and November 2010. Bone scanning and densitometry measurements were made with dual-emission X-ray absorptiometry. Lumbar-spine BMD (g/cm2) and BMD z-score were evaluated before and after treatment. The t test and Mann–Whitney U test were used for statistical analysis. Forty-three boys and 37 girls were followed for a median time of 6.0 years. Median calcium excretion before and after treatment was 5.0 and 2.6 mg/kg/24 h, respectively. The BMD z-score changed significantly from -0.763±0.954 (mean±SD) to -0.537± 0.898 (p<0.0001) before and after treatment, respectively. The BMD z-score of the patients improved with treatment, suggesting a beneficial effect and potential need for treatment. However, the lack of a control group points to the need for future studies to corroborate this outcome.
Pediatr Nephrol DOI 10.1007/s00467-011-1952-4 Received: 11 April 2011 / Revised: 8 June 2011 / Accepted: 10 June 2011
