Differences in MRI findings between subgroups of recent-onset childhood arthritis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Eva Kirkhus & Berit Flatø & Øystein Riise & Tor Reiseter & Hans-Jørgen Smith
- چاپ و سال / کشور: 2010
Description
Background MRI is sensitive for joint inflammation, but its ability to separate subgroups of arthritis in children has been questioned. Infectious arthritis (IA), postinfectious arthritis (PA), transient arthritis (TA) and juvenile idiopathic arthritis (JIA) are subgroups that may need early, different treatment. Objective To determine whether MRI findings differ in IA, PA/TA and JIA in recent-onset childhood arthritis. Materials and methods Fifty-nine children from a prospective study of incidence of arthritis (n=216) were, based on clinical and biochemical criteria, examined by MRI. Joint fluid, synovium, bone marrow, soft tissue and cartilage were scored retrospectively and analysed by Pearson chisquare test and logistic regression analysis. Results Fifty-nine children had MRI of one station. IA was suggested by bone marrow oedema (OR 7.46, P=0.011) and absence of T1-weighted and T2-weighted low signal intensity synovial tissue (OR 0.06, P=0.015). Furthermore, soft-tissue oedema and reduced contrast enhancement in the epiphyses were more frequent in children with IA. JIA correlated positively with low signal intensity synovial tissue (OR 13.30, P<0.001) and negatively with soft-tissue oedema (OR 0.20, P=0.018). No significant positive determinants were found for PA/TA, but bone marrow oedema, soft-tissue oedema, irregular thickened synovium and low signal intensity synovial tissue was less frequent than in IA/JIA. Conclusion In children with high clinical suspicion of recent onset arthritis, there was a significant difference in the distribution of specific MRI features among the diagnostic groups.
Pediatr Radiol (2011) 41:432–440 DOI 10.1007/s00247-010-1897-y Received: 6 March 2010 / Revised: 28 September 2010 / Accepted: 28 September 2010 / Published online: 7 December 2010
