Temperature modulated protein release from pH/temperature sensitive hydrogels
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Tae Gwan Park*
- چاپ و سال / کشور: 1999
Description
A hydrogel which exhibits a volume phase transition in response to pH as well as temperature has been synthesized and utilized as a matrix for the controlled release of insulin. Insulin crystals have been entrapped into the hydrogel matrix during the copolymerization process of N-isopropylacrylamide and the cationic monomer, N,N@-dimethylaminopropylmethacrylamide. The former allows the gel to exhibit a temperature sensitivity, and the latter gives the gel a pH-sensitivity. Insulin release proقles from the gel matrix have been investigated as functions of pH, temperature, and thermal cycling operation. Temperature and thermal cycling operations largely a¤ected the insulin release rate while pH variation did not signiقcantly inکuence the release proقles.
Biomaterials 20 (1999) 517-521 Received 8 September 1997; accepted 1 September 1998
