Multiple Functions of Rad9 for Preserving Genomic Integrity
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kazuhiro Ishikawa1,2,*, Hideshi Ishii2,*, Toshiyuki Saito3 and Keiichi Ichimura
- چاپ و سال / کشور: 2006
Description
DNA-damage checkpoints sense and respond to genomic damage. Human Rad9 (hRad9), an evolutionarily conserved gene with multiple functions for preserving genomic integrity, plays multiple roles in fundamental biological processes, including the regulation of the DNA damage response, cell cycle checkpoint control, DNA repair, apoptosis, transcriptional regulation, exonuclease activity, ribonucleotide synthesis and embryogenesis. This review examines work that provides significant insight into the molecular mechanisms of several individual cellular processes which might be beneficial for developing novel therapeutic approaches to cancerous diseases with genomic instability.
Current Genomics, 2006, 7, 477-480 Received on: July 19, 2006 - Revised on: November 8, 2006 - Accepted on: November 10, 2006
