Myostatin in the Pathophysiology of Skeletal Muscle
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Gilles Carnac2, Barbara Vernus1 and Anne Bonnieu1,*
- چاپ و سال / کشور: 2007
Description
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promising therapy for muscle wasting. Here we discuss the recent developments and the controversies in myostatin research, focusing on the molecular and cellular mechanisms underlying the actions of myostatin on skeletal muscle and the potential therapeutic role of myostatin on muscle-related disorders.
Current Genomics, 2007, 8, 415-422 Received on: September 14, 2007 - Revised on: October 12, 2007 - Accepted on: October 14, 2007
