Genetic and Environmental Factors in Complex Neurodevelopmental Disorders
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : K.M.J. van Loo and G.J.M. Martens*
- چاپ و سال / کشور: 2007
Description
Complex neurodevelopmental disorders, such as schizophrenia, autism, attention deficit (hyperactivity) disorder, (manic) depressive illness and addiction, are thought to result from an interaction between genetic and environmental factors. Association studies on candidate genes and genome-wide linkage analyses have identified many susceptibility chromosomal regions and genes, but considerable efforts to replicate association have been surprisingly often disappointing. Here, we summarize the current knowledge of the genetic contribution to complex neurodevelopmental disorders, focusing on the findings from association and linkage studies. Furthermore, the contribution of the interaction of the genetic with environmental and epigenetic factors to the aetiology of complex neurodevelopmental disorders as well as suggestions for future research are discussed.
Current Genomics, 2007, 8, 429-444 Received on: October 25, 2007 - Revised on: November 7, 2007 - Accepted on: November 9, 2007
