Towards Retinoid Therapy for Alzheimer’s Disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : K. Shudo1,*, H. Fukasawa2, M. Nakagomi1 and N. Yamagata1
- چاپ و سال / کشور: 2009
Description
Alzheimer’s disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and agerelated changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD
Current Alzheimer Research, 2009, 6, 302-311
