Gene therapy: Regulations, ethics and its practicalities in liver disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Xi Jin, You-Ming Li, Digestive Department, The First Affiliated Hospital, Medical School, Zhejiang University, Hangzhou 310003, Zhejiang Province, C
- چاپ و سال / کشور: 2008
Description
Gene therapy is a new and promising approach which opens a new door to the treatment of human diseases. By direct transfer of genetic materials to the target cells, it could exert functions on the level of genes and molecules. It is hoped to be widely used in the treatment of liver disease, especially hepatic tumors by using different vectors encoding the aim gene for anti-tumor activity by activating primary and adaptive immunity, inhibiting oncogene and angiogenesis. Despite the huge curative potential shown in animal models and some pilot clinical trials, gene therapy has been under fierce discussion since its birth in academia and the public domain because of its unexpected side effects and ethical problems. There are other challenges arising from the technique itself like vector design, administration route test and standard protocol exploration. How well we respond will decide the fate of gene therapy clinical medical practice.
Online Submissions: wjg.wjgnet.com World J Gastroenterol 2008 April 21; 14(15): 2303-2307 www.wjgnet.com World Journal of Gastroenterology ISSN 1007-9327 wjg@wjgnet.com © 2008 WJG. All rights reserved
