The Expanding Universe of .. .. T Lymphocytes: Subsets, Generation and Function
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Serena Meraviglia, Nadia Caccamo, Carmela La Mendola, Giuliana Guggino and Francesco Dieli*
- چاپ و سال / کشور: 2008
Description
.... T cells which express the V..9 and V..2 gene products are unique to primates and represent only a minor population of peripheral blood T lymphocytes. They recognize nonpeptidic phosphoantigens in an MHC-unrestricted fashion and show low dependence on costimulation. The ability of V..9V..2 T cells to develop immunological memory remains debated. V..9V..2 T cells are able to mount both immediate effector functions and memory anamnestic responses upon microbial reinfection, suggestive of the existence of different functional subsets. However, how V..9V..2 T cells mediate the different facets of a memory response remains largely obscure. In this review we highlight recent findings that demonstrate that V..9V..2 cells are a very heterogeneous population of T lymphocytes and possess phenotypic and functional features very close to those of conventional .... T lymphocytes: they comprise distinct naive, memory and effector populati
Current Immunology Reviews, 2008, 4, 183-189
