Foamy Virus Vectors
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : DAVID W. RUSSELL1,2* AND A. DUSTY MILLER1,3
- چاپ و سال / کشور: 1996
Description
Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.
JOURNAL OF VIROLOGY, Jan. 1996, p. 217–222 Received 20 July 1995/Accepted 28 September 1995
