Harnessing Dendritic Cells for Tumor Antigen Presentation
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Stefan Nierkens 1 and Edith M. Janssen 2,*
- چاپ و سال / کشور: 2011
Description
Abstract: Dendritic cells (DC) are professional antigen presenting cells that are crucial for the induction of anti-tumor T cell responses. As a consequence, research has focused on the harnessing of DCs for therapeutic interventions. Although current strategies employing ex vivo-generated and tumor-antigen loaded DCs have been proven feasible, there are still many obstacles to overcome in order to improve clinical trial successes and offset the cost and complexity of customized cell therapy. This review focuses on one of these obstacles and a pivotal step for the priming of tumor-specific CD8+ and CD4+ T cells; the in vitro loading of DCs with tumor antigens
Cancers 2011, 3, 2195-2213; doi:10.3390/cancers3022195 Received: 14 March 2011; in revised form: 14 April 2011 / Accepted: 19 April 2011 / Published: 26 April 2011
