HLA-DQA1 genotyping of Helicobacter pylori associated gastritis patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Nibras S. Al-Ammar1, Ihsan E. Al-Saimary1*, Saad Sh. Hamadi2, Ma Luo2, Trevor Peterson2 and Chris Czarnecki2
- چاپ و سال / کشور: 2011
Description
To study HLA-DQA1 genotyping in Helicobacter pylori associated gastritis patients. This study was carried out in College of Medicine, University of Basrah. HLA-DQA1 genotyping was done in College of Medicine, University of Manitoba, Winnipeg, Canada during the period from 17th of April 2009 to 15th of July 2010. A total of 100 patients (41 males and 59 females and a total of 30 controls (18 males and 12 females) were included in this study. DQA1 alleles frequencies were studied in 70 H. pylori associated gastritis patients and 30 healthy controls. DQA1*0201 decreased allele frequency was statistically not significant in H. pylori associated gastritis patients, but there was a strong association (odds ratio= 2.61, as compared with controls. In the present study many alleles from both locus showed high frequencies with a very strong association, but statistically not significant, this association has not been reported and it is important to note that a larger sample size should be studied.
Journal of Medical Genetics and Genomics Vol. 3(2), pp. 35 – 40, February 2011 Available online http://www.academicjournals.org/jmgg ISSN 2141-2278 ©2011 Academic Journals
