EMBRYONIC STEM CELLS/INDUCED PLURIPOTENT STEM CELLS
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : LUDOVIC VALLIER,a THOMAS TOUBOUL,a,b STEPHANIE BROWN,a CANDY CHO,a BILADA BILICAN,c MORGAN ALEXANDER,a JESSICA CEDERVALL,d SIDDHARTHAN CHANDRAN,c LAR
- چاپ و سال / کشور: 2009
Description
Human pluripotent stem cells from embryonic origins and those generated from reprogrammed somatic cells share many characteristics, including indefinite proliferation and a sustained capacity to differentiate into a wide variety of cell types. However, it remains to be demonstrated whether both cell types rely on similar mechanisms to maintain their pluripotent status and to control their differentiation. Any differences in such mechanisms would suggest that reprogramming of fibroblasts to generate induced pluripotent stem cells (iPSCs) results in novel states of pluripotency. In that event, current methods for expanding and differentiating human embryonic stem cells (ESCs) might not be directly applicable to human iPSCs. However, we show here that human iPSCs rely on activin/ nodal signaling to control Nanog expression and thereby
STEM CELLS 2009;27:2655–2666 www.StemCells.com
