Direct antiglobulin test (Coombs’) positive autoimmune hemolytic anemia induced by Epstein-Barr virus infectious mononucleosis in two children
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mehmet Akin*, Ӧzlem Şahin, Kazim Küçüktaşci, Burçin Kaya, Ersin Gozkeser, Murat Cağlar, and Firat Erdoğan
- چاپ و سال / کشور: 2011
Description
Primary Epstein-Barr virus infection in children is usually asymptomatic, but some children or young adults manifest infectious mononucleosis with typical symptoms of fever, pharyngitis, lymphadenopathy, hepatosplenomegaly and a typical lymphocytosis. The infection caused by Epstein- Barr Virus (EBV) can be followed by immunological complications. One of these is autoimmune hemolytic anemia (AIHA) that it is rare but well known ~1:1000 patients with infectious mononucleosis. Two male patients, aged 2 and 2.5 years old with autoimmune hemolytic anemia caused by Epstein- Barr virus admitted to our hospital with pallor, palpitation, fever and scleral icterus. Viral capsid antigen -IgM was positive in both cases, indicating the presence of primary Epstein-Barr virus infection. AIHA risk of EBV infection in the first two weeks might be considered closely because of life threatining complications such as autoimmune hemolytic anemia.
Journal of Infectious Diseases and Immunity Vol. 3(1), pp. 14-16, January 2011 Available online at http://www.academicjournals.org/JIDI ISSN 2141-2375 ©2011 Academic Journals Accepted 22 December, 2010
