A randomized pilot study of triple nucleotide reverse transcriptase inhibitors therapy with tenofovir, zidovudine (AZT) plus emtricitabine in antiretroviral naive HIV-1 infected patients – The TEAZE study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Markus Bickel*, Christoph Stephan, Tessa Lennemann, Pavel Khaykin, Gabi Nisius, Hans Reinhard Brodt, Schlomo Staszewski and Annette Haberl
- چاپ و سال / کشور: 2010
Description
A randomized pilot-study to evaluate the virologic efficacy of Tenofovir-DF (TDF) 300 mg/Emtricitabine (FTC) 200 mg once daily plus Zidovudine (AZT) 250 mg twice daily (armA) or 300 mg BID (armB) in naive HIV-1 infected patients. Twenty patients with a median CD4 cell count of 288 cells/ƒتl (standard deviation (SD): پ} 109) and a median viral load of 66.400 HIV RNA copies/ml (SD: پ} 70.700) were included. Three patients in armA and one in armB had a single HIV-RNA-PCR measurement of > 50 copies/ml (p = 0.58). The combined median CD4 cells increased by 188 cells/ƒتl at week 48. TDF 300 mg/FTC 200 mg once daily in combination with AZT 250 mg or 300 mg twice daily was well tolerated and no virologic failure occurred.
Journal of AIDS and HIV Research Vol. 2(2), pp. 101-103, August 2010 Available online http://www.academicjournals.org/jahr ISSN 2141-2359 ©2010 Academic Journals
