Polymorphism in the CC-chemokine receptor-5 (CCR5) gene and risk of AIDS among Kashmiri population
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Syed Irtiza1*, Dil-Afroze1, Niyaz A. Naykoo1, Lateef Charoo1, Iqbal Qasim1, Inayat S. Fazili1,2, Mir Aasif1 and Mushtaq A. Siddiqi1
- چاپ و سال / کشور: 2011
Description
Chemokine receptors and their ligands may confer resistance to HIV-1 infection and/or AIDS progression. Our aim was to study our population for the most frequently studied polymorphism CCR5- 32 for evaluating their contribution to a protective genetic background against HIV infection and progression. One hundred and fifty blood samples from normal controls were recruited at random among prospective normal blood donors and forty blood samples of HIV/AIDS patients from Ethnic Kashmiri population were collected from Blood Bank and National AIDS Control Organisation of Sheri Kashmir Institute of Medical Sciences Soura, Kashmir respectively. Genotyping was performed by polymerase chain reaction (PCR) analysis followed by electrophoresis. The CCR5- 32 genotype frequency among our study group was wt/wt (93.3%), wt/mt (4%) and mt/mt (3%) from control group, revealing CCR532 allele frequency of 5%. The frequency of the CCR5- 32 allele among our study population seems to be remarkably higher compared to previously reported frequencies in other Asian populations. However, since this polymorphism is related with delayed progression from HIV infection to AIDS, it could be used for prognostic genotyping in HIV infected Kashmiri individuals.
Journal of AIDS and HIV Research Vol. 3(5), pp. 103-106, May 2011 Available online http://www.academicjournals.org/jahr ISSN 2141-2359 ©2011 Academic Journals Accepted 25 March, 2011
