ادغام فارماکوکینتیک ، فارماکودینامیک و تاکسیکوکینتیک در توسعه منطقی دارو Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development
- نوع فایل : کتاب
- زبان : انگلیسی
- نویسنده : Carl C. Peck (auth.) ,Avraham Yacobi Ph.D. ,Jerome P. Skelly Ph.D. ,Vinod P. Shah Ph.D. ,Leslie Z. Benet Ph.D. ,Pharm.D.(Hon.) (eds.)
- ناشر : Springer US
- چاپ و سال / کشور: 1993
- شابک / ISBN : 978-1-4757-1522-4, 978-1-4757-1520-0
Description
Introduction: The Case for Preclinical Pharmacodynamics (G. Levy). Preclinical Pharmacokinetic and Pharmacodynamic Studies: Pharmacokinetics and Drug Metabolism in Animal Studies (G.G. Fitzgerald). Methodology for Preclinical Pharmacodynamic Studies: Preclinical Pharmacodynamics of Central Nervous System Active Agents (M. Danhof et al.). Preclinical and Clinical Pharmacokinetics: The Role of Pharmacokinetics in the Drug Development Process (L.Z. Benet). Clinical Pharmacodynamics: The Value of PlasmaWayfarin Measurement (R.A. O'Reilly). Application of Pharmacodynamics and Pharmacokinetics in the Drug Development Process: ConcentrationControlled Trials (L. Sanathanan, C.C. Peck). Summary Report: Opportunities for Integration of Pharmacokinetics, Pharmcodynamics, and Toxicokinetics in Rational Drug Development. 19 additional articles. Index.
