Overexpression of the EZH2, RING1 and BMI1 genes is com ...
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Leukemia stem cells
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Overexpression of the EZH2, RIN ...
Epigenetics refers to the study of clonally inherited changes in gene expression without accompanying genetic changes. Previous research on the epig ...
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Long-term follow-up of patients ...
Prior to introduction of imatinib mesylate, the median survival of chronic myeloid leukemia (CML) patients was approximately 60 months and the stand ...
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CYP2B6 gene single nucleotide p ...
CYP2B6 is a highly variable and polymorphic cytochrome P450 enzyme which plays a vital role in the degradation of some endogenous metabolites, xenob ...
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Sickle-cell disease and malaria ...
Sickle-cell disease (SCD) patients are at high risk of developing malaria which is a major contributor to morbidity andmortality in this disease. In ...
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Severe congenital neutropenia i ...
We have analysed a family with nine congenital neutropenia patients in four generations, several of which we have studied in a long-term follow-up o ...
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Additional erythrocytic and ret ...
Hereditary spherocytosis (HS) is characterised by weakened vertical linkages between the membrane skeleton and the red blood cell’s lipid bilayer, l ...
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Contribution of VKORC1 and CYP2 ...
Within the Asian populations, Indian patients had been reported to require higher warfarin dose compared with the Chinese and Malay patients, and th ...
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Impact of cytokine gene polymor ...
Autoreactive cytotoxic T cells play a key role in the pathogenesis of aplastic anemia (AA) by myelosuppressive cytokines including interferon-gamma, ...
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The role of zinc protoporphyrin ...
The differentiation between primary myelofibrosis (PMF) and essential thrombocythaemia (ET) may be difficult especially in early-stage disease. In P ...
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Leukemias induced by altered TR ...
Rapamycin is a potent allosteric mTORC1 inhibitor with clinical applications as an anticancer agent. However, only a fraction of cancer patients res ...
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Molecular characterization of a ...
Over 80% of the α-thalassemia cases in southern China are caused by large deletions involving the α-globin gene cluster on chromosome 16p13.3. Here, ...
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Cost-effectiveness of adenotons ...
In children with sickle cell disease (SCD), adenotonsillar hypertrophy or recurrent tonsillitis are frequently linked with an increased risk of obst ...
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A prospective study to assess t ...
This prospective study was carried out to assess the usefulness of five laboratory tests in the diagnosis of hereditary spherocytosis (HS), based on ...
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Oxidative stress contributes to ...
In the present study, we questioned the role of oxidative stress in hereditary spherocytosis (HS), where red blood cells (RBC) have a shortened surv ...
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Hydralazine and magnesium valpr ...
Decitabine and azacitidine, two DNA methyltransferase (DNMT) inhibitors, are the current standard of treatment for myelodysplastic syndrome (MDS). H ...
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Myeloid growth factors in acute ...
Randomized controlled trials (RCT) investigating administration of colony-stimulating factors (CSF) during or after chemotherapy in acute myeloid le ...
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Dysmetabolic hyperferritinemia ...
Hyperferritinemia is common in individuals with the metabolic syndrome (dysmetabolic hyperferritinemia), but its pathophysiology and the degree to w ...
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Deferasirox effectively decreas ...
Iron overload is present in several cases of double heterozygous sickle-cell/beta-thalassemia (HbS/β-thal). Deferasirox is an orally administered ir ...
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Quantitative analysis of Hb Bar ...
It has long been recognized that the presence of hemoglobin (Hb) Bart’s in newborn’s blood is associated with α-thalassemia. However, the automated ...
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Expansion of CD4+CD25+ regulato ...
Rapamycin has important roles in the modulation of regulatory T cells. We tried to expand CD4+CD25+ regulatory T cells (Treg cells) from umbilical c ...
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Leukemia stem cells
Leukemia-initiating cells (LICs) or leukemia stem cells (LSCs) are defined by their ability to form tumors after xenotransplantation in immunodefici ...
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Iron overload in MDS—pathophysi ...
Many patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop transfusional iron overload, which is exacerba ...
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Proliferation and differentiati ...
CD34 is the most frequently used marker for the selection of cells for bone marrow (BM) transplantation. The use of CD133 as an alternative marker i ...
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Variant of the extensor pollici ...
Variations on muscular and tendinous connections of the hand occur frequently in the human population and are often discovered during routine surgic ...
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A case of double aortic arch ac ...
During the elective course of human dissection at the University of Toyama in 2007, we encountered a rare case of double aortic arch accompanied by ...
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