Discoid lupus erythematosus: De ...
Discoid lupus erythematosus (DLE) is one of the most common forms of cutaneous lupus erythematosus (CLE). The purpose of this study was to evaluate t ...
Immunogenic evaluation of a rec ...
Typhoid poses a global public health concern. Presently available vaccines against typhoid have certain drawbacks that make them unsuitable for mass ...
Propranolol effect on prolifera ...
Beta-blockers are widely used drugs in cardiovascular diseases. Propranolol is a non selective betaadrenergic blocker extensively used in treatment o ...
Propranolol effect on prolifera ...
Beta-blockers are widely used drugs in cardiovascular diseases. Propranolol is a non selective betaadrenergic blocker extensively used in treatment o ...
Serological evidence for Chlamy ...
Increased mortality and morbidity with intracellular pathogens has been reported in females with diphtheria-tetanus-pertussis (DTP) as their most rec ...
Th17 Immunity in Patients with ...
Background: Allergic asthma is an inflammatory disease regulated by the T helper (Th) cells. The Th1/Th2 imbalance has been well documented in the p ...
The Role of Pemetrexed in Lung ...
Bronchioloalveolar carcinoma (BAC) and adenocarcinoma with bronchioloalveolar features (ADC-WBF) belong to the same anatomo-clinical entity and show ...
The Role of Pemetrexed in Advan ...
Pemetrexed is a newer antifolate drug that has been approved as first-line treatment for patients with advanced non-squamous, non-small cell lung can ...
The Role of Chemotherapy and Ra ...
Approximately one out of every three patients with non-small cell lung cancer (NSCLC) has locally advanced disease that is surgically unresectable. I ...
The Macrophage Stimulating Prot ...
Macrophage Stimulating Protein (MSP) is the only known ligand for the receptor tyrosine kinase Ron. The MSP/Ron pathway is involved in several import ...
Targeting Karyotypic Complexity ...
Multiple karyotypic abnormalities and chromosomal instability are characteristic features of many cancers that are relatively resistant to chemothera ...
Targeted Elimination of Leukemi ...
Despite recent advances, treatment of leukemia is often not curative. New insights indicate that this may be attributable to a small population of th ...
Should Adipokines be Considered ...
White adipose tissue (WAT) is an important endocrine organ that secretes approximately 30 biologically active peptides and proteins, collectively ter ...
Miliary tuberculosis with empye ...
We report a 39 year-old patient who presented with chest pain, malaise, lassitude, anorexia, weight loss, fever, chills, productive coughs, pleural p ...
Predictive Markers for Haematol ...
Pemetrexed is a multi-targeted anti metabolite that inhibits several key folate-dependent enzymes in the thymidine and purine biosynthetic pathways, ...
Pharmacological Aspects of the ...
Conventional regimens have limited impact against NSCLC. Current research is focusing on multiple pathways as potential targets, and this review desc ...
Pemetrexed: Potential Role in t ...
Platinum-based doublet chemotherapy is now established as a standard of care in the adjuvant treatment of resected stage II and stage IIIA nonsmall c ...
MicroRNA-21: From Cancer to Car ...
MicroRNA-21 (miR-21) expression is activated in multiple types of cancers, such as breast, liver, brain, prostate, myometrial cancers but also in car ...
Involvement of the Toxic AGEs ( ...
Diabetic vascular complications are leading causes of acquired blindness, end-stage renal failure, a variety of neuropathies, and accelerated atheros ...
Intercalation of Erlotinib and ...
Both the multi-targeted antifolate pemetrexed and the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib have establis ...
Incretin-Based Therapies in Pat ...
Type 2 diabetes mellitus (T2DM) is a highly prevalent and progressive metabolic disease associated with significant morbidity and mortality. While gl ...
Heme Oxygenase-1 in Tumor Biolo ...
Heme oxygenase-1 (HO-1) degrades heme to carbon monoxide (CO), biliverdin, and ferrous iron. As HO-1 expression is highly increased by stressful cond ...
Cloning, high level expression ...
Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release from peripheral cholinergic synapses. BoNTs consist of a toxifying light chain and a h ...
Cloning and expression of a reg ...
An assay for the endopeptidase activities of clostridial neurotoxins in contaminated biotherapeutic products has been developed. Based on a synthetic ...
Coenzyme Q10 in Neuromuscular a ...
Coenzyme Q10 (CoQ10, or ubiquinone) is an electron carrier of the mitochondrial respiratory chain (electron transport chain) with antioxidant propert ...