Clinicopathologic and molecular ...
Akt/PKB serine/threonine kinase is a leading signalling modulator for several cellular processes including metabolism, growth, proliferation and sur ...
Distinct function of androgen r ...
Steroid receptor coactivators are important in regulating the function of the receptors in endocrine organ development and in cancers, including bre ...
Insulin like growth factor bind ...
Previously, we have shown that insulin-like growth factor binding protein-7 (IGFBP-7) expression is inversely correlated with disease progression in ...
Targeting trastuzumab-resistant ...
Targeting HER-2 over-expressing breast cancer cells with trastuzumab has resulted in significant improvements in both disease-free and overall survi ...
Does radiotherapy planning with ...
This prospective study investigated radiation dose and volume changes during breathing cycle. Ten patients with left breast carcinoma receiving radi ...
Identification of immunodominan ...
Mammaglobin-A (MGBA), a 10-kD protein, is over expressed in 80% of primary and metastatic human breast cancers. Breast cancer patients demonstrate h ...
Prevalence of the variant allel ...
Recently, a variant allele in the 30UTR of the KRAS gene (rs61764370 T[G) was shown to be associated with an increased risk for developing non-small ...
Tumor–stroma ratio in the prima ...
Stroma tissue surrounding cancer cells plays an important role in tumor development and behavior. In colorectal cancer, it has been found that the a ...
International distribution and ...
The c.156_157insAlu BRCA2 mutation has so far only been reported in hereditary breast/ovarian cancer (HBOC) families of Portuguese origin. Since thi ...
The rexinoid bexarotene repress ...
Bexarotene is an RXR-selective vitamin A analog that has been shown to prevent ER-negative mammary tumorigenesis in animal models. While investigati ...
Targeting mutant p53 protein an ...
Breast cancer progression depends upon the elaboration of a vasculature sufficient for the nourishment of the developing tumor. Breast tumor cells f ...
Three-dimensional collagen repr ...
The behavior of breast epithelial cells is influenced by their microenvironment which includes stromal cells and extracellular matrix (ECM). During ...
Oral fluoropyrimidine may augme ...
The present preclinical study was designed to evaluate a new combination therapy comprised of the aromatase inhibitor anastrozole (ANA) and the oral ...
RAD51 135G>C does not modify ...
A single-nucleotide polymorphism (SNP) in the 50-untranslated region (UTR) of RAD51, 135G[C (rs1801320), was reported to be associated with an incre ...
Nicotine-induced human breast c ...
Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholin ...
Interactions between breast can ...
The preferential metastasis of breast cancer cells to bone is a complex set of events including homing and preferential growth which may include uni ...
Let-7 family miRNAs regulate es ...
In order to understand how microRNAs (miRNAs) regulate breast cancer tumorigenesis, a miRNA expression microarray screening was performed using RNA ...
Combined Src and ER blockade im ...
Antiestrogen therapies arrest susceptible estrogen receptor (ER)-positive breast cancers by increasing p27. Since Src phosphorylates p27 to promote ...
COX2 expression in prognosis an ...
In breast cancer, the prognostic impact of COX2 expression varies widely between studies. We examined the prognostic value of COX2 expression in a ...
GRB7 protein over-expression an ...
The growth factor receptor-bound protein-7 gene (GRB7) encodes a multi-domain signal transduction molecule. The purpose of this study was to examine ...
The TGF-b/Smad pathway induces ...
Transforming growth factor-b (TGF-b) has opposing roles in breast cancer progression by acting as a tumor suppressor in the initial phase, but stimu ...
High immunogenic potential of p ...
As pre-existent immunity might be a reflection of an emerging anticancer response, the demonstration of spontaneous T-cell responses against tumor a ...
The liver receptor homolog-1 re ...
Estrogen receptor-a (ER) is expressed in the great majority of breast cancers, and the inhibition of ER action is a key part of breast cancer treatm ...
The anti-diabetic drug metformi ...
We here demonstrate that the anti-diabetic drug metformin interacts synergistically with the anti-HER2 monoclonal antibody trastuzumab (Tzb; Hercept ...
The benefits of discussing adju ...
Breast cancer patients must often decide between multiple adjuvant therapy options to prevent cancer recurrence. Standard practice, as implemented i ...